A total of 102,025 new HIV infections were recorded across Nigeria's 36 states and the Federal Capital Territory in 2025, according to the Federal Ministry of Health and Social Welfare's State of the Health of the Nation Report 2025. The report provides a state-by-state breakdown of new cases despite ongoing efforts to curb the spread of the virus.

Lagos State recorded the highest number of new HIV infections with 10,430 cases. Rivers State followed with 6,287 new infections, while Kano State recorded 6,106 cases, making them the states with the highest number of newly reported infections during the year.

The report also showed that Akwa Ibom recorded 5,413 new HIV infections, underscoring the continued need for strengthened prevention, testing, treatment, and public awareness campaigns across the country.